PET and SPECT imaging of neurotoxicity
bookPart
From conception until death, we are exposed to neurotoxins that can potentially induce toxic encephalopathy. Neurotoxins can cause acute adverse effects or show delayed symptoms. They can even induce impaired brain development in the offspring of exposed pregnant females. Both in patients and in animals, it can be diffi cult to establish the effects of toxins on the (developing) brain. Functional imaging with positron emission tomography (PET) or single photon emission computed tomography (SPECT) could provide useful tools for preclinical testing of (developmental) neurotoxicity of potential toxic substances. These techniques could also aid clinicians in determining the damage that was done to brain functioning by exposure to a neurotoxin, and they may provide insight in the mechanisms that are involved in the intoxication. This book chapter reviews the potential applications of PET and SPECT imaging in (developmental) neurotoxicity testing and evaluation of functional defi cits in the brain after exposure to neurotoxins. © Springer-Verlag Berlin Heidelberg 2014.
TNO Identifier
532852
ISBN
9783642543074
9783642543067
9783642543067
Publisher
Springer Berlin Heidelberg
Source title
Pet and Spect in Neurology
Editor(s)
Dierckx, R.A.J.O.
Otte, A.
Vries, E.F.J. de
Waarde, A. van
Leenders, K.L
Otte, A.
Vries, E.F.J. de
Waarde, A. van
Leenders, K.L
Pages
775-795
Files
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