The art of targeting gut microbiota for tackling human obesity
article
Recently, a great deal of interest has been expressed regarding strategies to tackle worldwide obesity because of its accelerated wide spread accompanied with numerous negative effects on health and high costs. Obesity has been traditionally associated with an imbalance in energy consumed when compared to energy expenditure. However, growing evidence suggests a less simplistic event in which gut microbiota plays a key role. Obesity, in terms of microbiota, is a complicated disequilibrium that presents many unclear complications. Despite this, there is special interest in characterizing compositionally and functionally the obese gut microbiota with the help of in vitro, animal and human studies. Considering the gut microbiota as a factor contributing to human obesity represents a tool of great therapeutic potential. This paper reviews the use of antimicrobials, probiotics, fecal microbial therapy, prebiotics and diet to manipulate obesity through the human gut microbiota and reveals inconsistencies and implications for future study. © 2015, Springer-Verlag Berlin Heidelberg.
Topics
ObesityGut microbiotaFecal transplantationProbioticsPrebioticsDietAntiinfective agentChlortetracyclineOxytetracyclinePrebiotic agentProbiotic agentShort chain fatty acidAntimicrobial therapyBacterial endocarditisBifidobacteriumBifidobacterium adolescentisBifidobacterium animalisBifidobacterium longumBifidobacterium pseudocatenulatumBody heightBody massDietDrug useDysbiosisEndotoxemiaFecal microbial therapyFeces microfloraFood intakeGluconeogenesisGlucose toleranceInnate immunityIntestine floraLactobacillus gasseriLactobacillus rhamnosusLong term careMethanobrevibacter smithiiMolecular evolutionNonhumanProtein blood levelReviewEeight gainAnimalia
TNO Identifier
525441
Source
Genes & Nutrition, 10(20), pp. 12 p..
Pages
12 p.
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