A novel safety assessment strategy applied to non-selective extracts
article
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult to determine. Here, a pragmatic novel safety assessment strategy is applied to the production of non-selective extracts (NSEs), used for different purposes in food such as for colouring purposes, which are complex food mixtures prepared from reference juices. The Complex Mixture Safety Assessment Strategy (CoMSAS) is an exposure driven approach enabling to efficiently assess the safety of the NSE by focussing on newly formed substances or substances that may increase in exposure during the processing of the NSE. CoMSAS enables to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure. This will reduce the amount of work needed for identification, characterisation and safety assessment of unknown substances detected at low concentration, without the need for toxicity testing using animal studies. In this
paper, the CoMSAS approach has been applied for elderberry and pumpkin NSEs used for food colouring purposes.
paper, the CoMSAS approach has been applied for elderberry and pumpkin NSEs used for food colouring purposes.
Topics
Non-selective extractStrategyThreshold of toxicological concernTTCProcessingAflatoxinAzoxy derivativeBiphenyl derivativeCarbamic acid derivativeChemical compoundDibenzodioxin derivativeDibenzofuran derivativeMiscellaneous drugs and agentsNitroso derivativeOrganophosphatePolymerProteinSemi volatile substanceSteroidSugarUnclassified drugVolatile agentWaterYoghurtAllergenicityAnalytical parametersAshChemical analysisChemistryComparative studyComplex mixture safety assessment strategyConcentration (parameters)Controlled studyDietary fiberDrug mixtureExposureFood colorFood compositionFuit gumFruit juiceGenotoxicityHazard assessmentIce creamLiquid chromatographyLiquid liquid extractionMass fragmentographyNonhumanPrevention and controlProceduresRisk assessmentSambucusSoft drinkSolid phase extractionSolid phase microextractionSquashThreshold of toxicological concernToxicity testingFood AnalysisFood ContaminationFood HandlingFood SafetyGas Chromatography-Mass SpectrometryHazard Analysis and Critical Control PointsHumansPrevention and controlToxicityAnimalia
TNO Identifier
523831
Source
Food and Chemical Toxicology, 80, pp. 163–181.
Pages
163–181
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