Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis
article
Objective: To evaluate the association between synovitis on contrast enhanced (CE) MRI with microscopic and macroscopic features of synovial tissue inflammation. Method: Forty-one patients (mean age 60 years, 61% women) with symptomatic radiographic knee OA were studied: twenty underwent arthroscopy (macroscopic features were scored (0-4), synovial biopsies obtained), twenty-one underwent arthroplasty (synovial tissues were collected). After haematoxylin and eosin staining, the lining cell layer, synovial stroma and inflammatory infiltrate of synovial tissues were scored (0-3). T1-weighted CE-MRI's (3T) were used to semi-quantitatively score synovitis at 11 sites (0-22) according to Guermazi etal. Spearman's rank correlations were calculated. Results: The mean (SD) MRI synovitis score was 8.0 (3.7) and the total histology grade was 2.5 (1.6). Median (range) scores of macroscopic features were 2 (1-3) for neovascularization, 1 (0-3) for hyperplasia, 2 (0-4) for villi and 2 (0-3) for fibrin deposits.The MRI synovitis score was significantly correlated with total histology grade [. r=0.6], as well as with lining cell layer [. r=0.4], stroma [. r=0.3] and inflammatory infiltrate [. r=0.5] grades. Moreover, MRI synovitis score was also significantly correlated with macroscopic neovascularization [. r=0.6], hyperplasia [. r=0.6] and villi [. r=0.6], but not with fibrin [. r=0.3]. Conclusion: Synovitis severity on CE-MRI assessed by a new whole knee scoring system by Guermazi etal. is a valid, non-invasive method to determine synovitis as it is significantly correlated with both macroscopic and microscopic features of synovitis in knee OA patients.
Chemicals/CAS: gadolinium, 7440-54-2
Tradenames: dotaremPhilips Achieva, Philips, Netherlands
Chemicals/CAS: gadolinium, 7440-54-2
Tradenames: dotaremPhilips Achieva, Philips, Netherlands
Topics
MacroscopyMRIOsteoarthritisSynovial tissueSynovitisGadoliniumAdultClinical articleCorrelational studyFemaleFibrin depositionHistology tissueHyperplasiaJoint biopsyKellgren Lawrence scaleKnee arthroplastyKnee arthroscopyKnee osteoarthritisMaleMicroscopyNamed inventories, questionnaires and rating scalesNeovascularization (pathology)Nuclear magnetic resonance imagingNuclear magnetic resonance scannerObservational studyOutcome assessmentPain severityRadiological parametersSynovitisSynoviumVisual analog scaleX ray film
TNO Identifier
519619
ISSN
10634584
Source
Osteoarthritis and Cartilage, 22(10), pp. 1606-1613.
Pages
1606-1613
Files
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