Protein detection on biotin-derivatized polyallylamine by optical microring resonators

article







Ullien, D.

Harmsma, P.J.

Chakkalakkal Abdulla, S.M.C.

Boer, B.M. de

Bosma, D.

Sudhölter, E.J.R.

Smet, L.C.P.M. de

Jager, W.F.
Silicon optical microring resonators (MRRs) are sensitive devices that can be used for biosensing. We present a novel biosensing platform based on the application of polyelectrolyte (PE) layers on such MRRs. The top PE layer was covalently labeled with biotin to ensure binding sites for antibodies via a streptavidin-biotin binding scheme. Monitoring the shift in the microring resonance wavelength allows realtime, highly sensitive detection of the biomolecular interaction. © 2014 Optical Society of America.
Topics









Optical resonatorsBiomolecular interactionsBiosensing platformsHighly sensitive detectionsMicroring resonanceOptical microring resonatorPolyallylamineProtein detectionSensitive devicesCoenzymes
TNO Identifier
513442
Repository link
https://resolver.tno.nl/uuid:146357c3-73ad-44da-b712-2c8d84c8a00b
ISSN
10944087
Source
Optics Express, 22(13), pp. 16585-16594.
Publisher
Optical Society of American (OSA)
Collation
9 p.
Pages
16585-16594
Files
To receive the publication files, please send an e-mail request to TNO Repository.