Effect of moderate alcohol consumption on fetuin-A levels in men and women: Post-hoc analyses of three open-label randomized crossover trials
article
Background: Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data from clinical trials are lacking. Thus, we evaluated whether moderate alcohol consumption decreases circulating levels of fetuin-A. Methods. We analyzed data of three separate open-label, randomized, crossover trials: 1) 36 postmenopausal women consuming 250 ml white wine (25 g alcohol) or white grape juice daily for 6 weeks, 2) 24 premenopausal women consuming 660 ml beer (26 g alcohol) or alcohol-free beer daily for 3 weeks, and 3) 24 young men consuming 100 ml vodka (30 g alcohol) orange juice or only orange juice daily for 4 weeks. After each treatment period fasting blood samples were collected. Results: Circulating fetuin-A concentrations decreased in men after vodka consumption (Mean ± SEM: 441 ± 11 to 426 ± 11 μg/ml, p = 0.02), but not in women after wine (448 ± 17 to 437 ± 17 μg/ml, p = 0.16) or beer consumption (498 ± 15 to 492 ± 15 μg/ml, p = 0.48) compared to levels after each corresponding alcohol-free treatment. Post-hoc power analyses indicated that the statistical power to detect a similar effect as observed in men was 30% among the postmenopausal women and 31% among the premenopausal women. Conclusions: In these randomized crossover trials, moderate alcohol consumption decreased fetuin-A in men but not in women. This sex-specific effect may be explained by the relatively short intervention periods or the low statistical power in the trials among women. Trials registration. ClinicalTrials.gov ID no's: NCT00285909, NCT00524550, NCT00918918. © 2014 Joosten et al.; licensee BioMed Central Ltd.Chemicals/CAS: adiponectin, 283182-39-8; alanine aminotransferase, 9000-86-6, 9014-30-6; alcohol, 64-17-5; alkaline phosphatase, 9001-78-9; aspartate aminotransferase, 9000-97-9; gamma glutamyltransferase, 85876-02-4; glucose, 50-99-7, 84778-64-3; insulin, 9004-10-8
Topics
Alcohol consumptionFetuin-AInsulin sensitivityLiver enzymesType 2 diabetes mellitusAdiponectinAlanine aminotransferaseAlcoholAlkaline phosphataseAspartate aminotransferaseFatty acidGamma glutamyltransferaseGlucoseHigh density lipoprotein cholesterolInsulinLow density lipoprotein cholesterolTriacylglycerolAdultBeerBlood samplingConcentration (parameters)Controlled studyCrossover procedureFemaleGrape juiceHumanInsulin sensitivityIntervention studyMaleOpen studyOrange juicePost hoc analysisPostmenopausePremenopausePriority journalRandomized controlled trialSex differenceVodkaWhite wine
TNO Identifier
492970
ISSN
17585996
Source
Diabetology and Metabolic Syndrome, 6(1)
Article nr.
24