Long-term dietary sodium, potassium and fluid intake; Exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
article
Background:As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC.Methods:The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses.Results:Sodium intake increased RCC risk (P-trend=0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction=0.02).Conclusion:Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low. © 2014 Cancer Research UK.
Topics
TNO Identifier
489148
ISSN
00070920
Source
British Journal of Cancer, 110(3), pp. 797-801.
Pages
797-801