Risk factors for congenital anomalies in the Netherlands : poster presentation
article
Objectives: To determine the relation between several potential risk factors and the risk of having a newborn with one or more congenital anomalies. Participants: Data on 1,594,380 registered newborns from the Netherlands Perinatal Registry database were analysed. Logistic regression models were used to estimate the risk of having a newborn with anomalies. Results: All studied risk factors were significantly related to the risk of having a newborn with anomalies. The highest adjusted risks were observed for preexisting maternal diabetes (OR=2.0) and maternal epilepsy (OR=2.1). For maternal diabetes the risk was especially elevated in the cardiovascular system and for maternal epilepsy in the central nervous system. High maternal age, IVF/ICSI pregnancy, male gender and plurality were also strongly related to the risk of having a newborn with anomalies. The PARs were especially high for male gender, primiparity, high maternal age and non-Western ethnicity (respectively 18.4, 5.0, 2.5 and 1.7). The PARs for maternal diabetes, epilepsy and IVF/ICSI were very small as the prevalence of these risk factors in the general population is very low. In total 30% of the registered anomalies could be ascribed to the studied risk factors. Conclusions: Strategies for primary prevention of congenital anomalies should focus on different risk factors depending on the approach used. For a highrisk group approach existing maternal morbidity such as diabetes and epilepsy are important factors. For a public health approach, however, factors such as high maternal age, primiparity and ethnicity are more important to focus on, for example in preconception counselling.
TNO Identifier
529492
Source
Pediatric Research, 68, pp. 235.
Pages
235
Files
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