Exploring an orbitrap analyzer for the characterization of intact antibodies by native mass spectrometry
article
Monoclonal antibodies (mAbs) represent a major class of therapeutic biomolecules being developed by the biopharmaceutical industry, their popularity largely being a result of their high specificity towards targets. Therapeutic mAbs are being developed for various diseases, with a strong focus on cancer and immunological disorders.[1] All antibody drugs currently approved for clinical use are based on the immunoglobulin G (IgG) class; these molecules are composed of two heavy chains and two light chains, connected by disulfide bonds, and with a molecular weight of approximately 150 kDa. Antibody-based biopharmaceuticals can be complex and heterogeneous molecules, and a range of analytical tools are necessary to characterize them fully.
Topics
TNO Identifier
526121
Source
Angewandte Chemie - International Edition, 51(December), pp. 12992-12996.
Pages
12992-12996
Files
To receive the publication files, please send an e-mail request to TNO Repository.