Constitutive synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) : Conditions and therapeutic targets
article
In the population at large and in individual normal volunteers, baseline molar concentratios of t-PA and PAI-1 in plasma show a strong correlation. Evidence is summarized that insulin resistance is a prominent cause of interindividual variation, next to possible contributions of vascular inflammation and steroid hormones. In healthy volunteers, the coordinated elevation of both t-PA and PAI-1 in plasma is associated with a decrease in free, circulating, active t-PA. Evaluation of our knowledge about the mechanisms causing the observed coordinated appearance of t-PA and PAI-1, reveals basic deficiencies in knowledge about involvement of synthesis and clearance. Several independent epidemiological studies have shown that risk for cardiovascular events is associated with increased molar concentrations of t-PA or PAI-1, or with a decreased plasma t-PA activity. It is hypothesized that this represents a state of related increase in molar concentrations of t-PA and PAI-1, and that these risk indicators are interrelated. This hypothesis requires further validation in prospective epidemiological research in which all variables are studied simultaneously, with adequate methodology.
Chemicals/CAS: plasminogen activator inhibitor 1, 140208-23-7; tissue plasminogen activator, 105913-11-9
Chemicals/CAS: plasminogen activator inhibitor 1, 140208-23-7; tissue plasminogen activator, 105913-11-9
Topics
TNO Identifier
232515
ISSN
02689499
Source
Fibrinolysis, 8(SUPPL. 2), pp. 1-7.
Pages
1-7
Files
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