Acute release of tissue-type plasminogen activator (t-PA) from the endothelium ; regulatory mechanisms and therapeutic target

article



Schrauwen, Y.

Vries, R.E.M. de

Kooistra, T.

Emeis, J.J.
The acute release of t-PA was studied in vitro in human endothelial cells from different origin. It proved possible to enhance the amounts of t-PA which can be released by increasing t-PA synthesis, both in vitro, and in vivo in rats. These data suggest the feasibility to induce and (or) enhance acute release of t-PA in man.
Chemicals/CAS: bradykinin, 58-82-2, 5979-11-3; butyric acid, 107-92-6, 156-54-7, 461-55-2; retinoic acid, 302-79-4; thrombin, 9002-04-4; tissue plasminogen activator, 105913-11-9
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endotheliumfibrinolysisregulated secretiontissue-type plasminogen activator (t-PA)bradykininbutyric acidcholera toxinretinoic acidthrombintissue plasminogen activatoranimal cellanimal experimentconference paperendothelium cellfibrinolysisprotein secretionrat
TNO Identifier
232417
Repository link
https://resolver.tno.nl/uuid:d53f5c3d-61c5-49c2-aef3-319069cfa7e0
ISSN
02689499
Source
Fibrinolysis, 8(SUPPL. 2), pp. 8-12.
Pages
8-12
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