Active avoidance behavior in guinea pigs: Effects of physostigmine and scopolamine

article


Philippens, I.H.C.H.M.

Melchers, B.P.C.

Wolthuis, O.L.
Behavioral training of guinea pigs by conventional methods, such as used for rats and mice, appears difficult. Hence, only a few behavioral experiments with guinea pigs have been described in the literature. An active avoidance technique in an automated two-way shuttlebox is described using sound as a conditioned (CS) and a tactile stimulus (a stream of air ruffling their fur) as an unconditioned (UCS) stimulus. Acquisition is fairly rapid and reproducible. Doses of physostigmine that caused moderate blood acetylcholinesterase inhibition induced dose-dependent performance decrements. These decrements were counteracted by a sign-free dose of scopolamine.
Topics























Active avoidanceBehaviorGuinea pigPhysostigmineScopolamineShuttleboxAcetylcholinesteraseAnimal experimentAvoidance behaviorDrug antagonismEnzyme activityGuinea pigLearningMaleAcoustic stimulationAnimalAvoidance learningDose-response relationship, DrugAnimaliaCaviaCavia porcellusSus scrofaPhysostigmine, 57-47-6Scopolamine, 51-34-3
TNO Identifier
231893
Repository link
https://resolver.tno.nl/uuid:67ffff18-1efe-4057-a7d5-b415a78e77fb
ISSN
00913057
Source
Pharmacology Biochemistry and Behavior, 42(2), pp. 285-289.
Pages
285-289
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