Glycosylphosphatidyl inositol-linked membrane protein expression by intestinal intraepithelial lymphocytes
article
Murine intestinal intraepithelial lymphocytes (ilEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ ilEL contain high numbers of Thy-1-cells. This negativity of ilEL for Thy-1, a glycosylphosphatidyl inositol (GPI)-linked membrane protein, is not the result of conformational changes of the Thy-1 molecule. The absence of Thy-1 on TCRγδ+ and a subset of TCRαβ+ ilEL is furthermore not caused by a general defect in the processing of GPI-linked proteins, since Thy-1-ilEL mainly express another GPI-linked protein, Qa-2. However, TCRαβ+ and TCRγδ+ ilEL are also virtually negative for two other members of this family of activation-associated GPI-linked proteins, Ly-6A and Ly-6C. This unusual pattern of GPI-linked protein expression on TCR+ ilEL may be related to differences in cellular activation and signal transduction pathways between TCR+ ilEL and regular peripheral T cells. Chemicals/CAS: Antigens, Ly; Antigens, Surface; Antigens, Thy-1; Glycosylphosphatidylinositols; Membrane Glycoproteins; Receptors, Antigen, T-Cell, alpha-beta
Topics
glycosylphosphatidyl inositolT cell activationglycosylphosphatidylinositolanimal cellanimal experimentantigen expressionarticlecontrolled studyepithelium cellintestinemalemousenonhumanpriority journalt lymphocyte activationAnimalAntigens, LyAntigens, SurfaceAntigens, Thy-1GlycosylphosphatidylinositolsMembrane GlycoproteinsMiceMice, Inbred DBAReceptors, Antigen, T-Cell, alpha-betaSupport, Non-U.S. Gov'tT-Lymphocyte Subsets
TNO Identifier
231830
ISSN
09538178
Source
International Immunology, 4(8), pp. 899-903.
Pages
899-903
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