Safety profile of Hoodia gordonii extract: Mouse prenatal developmental toxicity study
article
Hoodia gordonii extract (0, 5, 15 or 50. mg/kg body weight/day, n= 24 mice/group) was orally administered by gavage to female CD-1 mice from gestation days 5-17. On gestation day 18 the females were euthanized and examined. Treatment at 50. mg/kg/day caused a marked reduction in feed intake and body weight gain. Feed consumption was sporadically reduced at 15. mg/kg/day. At 50 or 15. mg/kg/day fetal weights, ossification of some bones and full and empty uterus weights were reduced. There were no clear maternal or fetal effects at 5. mg/kg/day. Reproductive indices were unaffected at all doses and there were no treatment-related malformations, anomalies or variations. The overall study no-observed-adverse-effect level was set at 5. mg/kg/day. In summary, at doses that reduced maternal feed consumption, H. gordonii extract delayed fetal development. The fetal effects seen could be consequent to reduced maternal feed consumption, the desired biological activity of the test item. © 2011 Elsevier Ltd.
Topics
TNO Identifier
447269
ISSN
02786915
Source
Food and Chemical Toxicology, 50(SUPPL. 1), pp. S20-S25.
Pages
S20-S25
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