Safety profile of Hoodia gordonii extract: Rabbit prenatal developmental toxicity study
article
Hoodia gordonii extract was orally administered by gavage to groups of 22 female New Zealand white rabbits from day 3-28 after mating at doses of 0 (control), 3, 6 or 12. mg/kg bodyweight/day. These doses were reached by a dose escalation phase between days 3 and 7 after mating. As well as a vehicle control group, a control group pair-fed to the high dose was also included. On day 29 after mating the females were euthanized and examined. Treatment at 6 or 12. mg/kg/day was associated with a dose-related reduction in feed intake and bodyweight gain. Feed consumption and bodyweight gain was unaffected at 3. mg/kg/day. In spite of marked maternal effects at 12. mg/kg/day, reproductive indices were unaffected at all doses and there were no effects on fetal or placental weights and no morphological changes in the fetuses. The no-observed-effect level (NOEL) for developmental effects was therefore 12. mg/kg/day, and the maternal NOEL was 3. mg/kg/day. At doses that caused marked maternal effects, H. gordonii extract did not affect embryonic or fetal development in a species that is considered predictive of developmental toxicity in man. © 2011 Elsevier Ltd.
Topics
TNO Identifier
447268
ISSN
02786915
Source
Food and Chemical Toxicology, 50(SUPPL. 1), pp. S26-S33.
Pages
S26-S33
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