Subchronic (13-week) oral toxicity of neohesperidin dihydeochalcone in rats
article
Neohesperidin dehydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high-dose group, a marked caecal enlargement occurred in both sexes, accompanied by soft stools in the early stages of the study, somewhat lower plasma urea concentations and increased plasma alkaline phosphatase activity and a decreased urinary pH. This group also showed slight growth depression accompanied by transient reduction in food intake; in males the body weights remained relatively low throughout the experimental period. Furthermore, bilirubin level was increased in females and total period level was decreased in males of the high-dose group. The above changes were considered adaptive responses or change effects rather than manifestations of clear toxicity. The low- and intermediate-dose groups did not show any compound-related untoward effect. It was concluded that the intermediate dose, providing an overall intake of about 750 mg neohesperidin dihydrochalcone per kg body weight per day, was the no-effect level. Chemicals/CAS: Alkaline Phosphatase, EC 3.1.3.1; Bilirubin, 635-65-4; Blood Proteins; Chalcone, 94-41-7; Hesperidin, 520-26-3; neohesperidin dihydrochalcone, 20702-77-6; Sweetening Agents; Urea, 57-13-6.
Topics
bilirubinneohesperidin dihydrochalconeunclassified druganimal experimentarticlececumchronic toxicityfemalemalenonhumanoral drug administrationpriority journalratAdministration, OralAlkaline PhosphataseAnimalBilirubinBlood ProteinsBody WeightCecumChalconeDrinkingDrug StabilityEatingFemaleHesperidinMaleOrgan WeightRandom AllocationRatsRats, Inbred StrainsSupport, Non-U.S. Gov'tSweetening AgentsUreaAnimaliaRattus norvegicus
TNO Identifier
231250
ISSN
02786915
Source
Food and Chemical Toxicology, 28(7), pp. 507-513.
Pages
507-513
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