Parametric array technique for microbubble excitation
article
This study investigates the use of an acoustic parametric array as a means for microbubble excitation. The excitation wave is generated during propagation in a nonlinear medium of two high-frequency carrier waves, whereby the frequency of the excitation wave is the difference frequency of the carrier waves. Carrier waves of around 10 and 25 MHz are used to generate low-frequency waves between 0.5 and 3.5 MHz at amplitudes in the range of 25 to 80 kPa in water. We demonstrate with high-speed camera observations that it is possible to induce microbubble oscillations with the low frequency signal arising from the nonlinear propagation process. As an application, we determined the resonance frequency of Definity contrast agent microbubbles with radius ranging from 1.5 to 5 μm by sweeping the difference frequency in the range from 0.5 to 3.5 MHz. © 2011 IEEE.
TNO Identifier
430122
ISSN
08853010
Source
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 58(5), pp. 924-934.
Article nr.
No.: 5776747
Pages
924-934
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