Assignment of the human gene for histidine-rich glycoprotein to chromosome 3

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Berg, E.A. van den

Clercq, E. Le

Kluft, C.

Koide, T.

Zee, A. van der

Oldenburg, M.

Wijnen TH., J.

Meera Khan, P.
Histidine-rich glycoprotein (HRG) is a monomeric plasma glycoprotein involved in the modulation of coagulation and fibrinolysis. Using Southern analysis of human-rodent somatic cell hybrid DNA with a human HRG-specific cDNA probe, the HRG gene was assigned to chromosome 3. One hybrid that was known to contain only a segment of chromosome 3 also reacted positively with the HRG probe. Hybridization analysis with a set of chromosome 3-specific probes showed that the segment of chromosome 3 present in this hybrid is missing the region pter-p14, which indicates that HRG is not located in this region. No restriction fragment length polymorphisms were detected for HRG with 10 commonly used restriction enzymes. Chemicals/CAS: Glycoproteins; histidine-rich proteins; Proteins
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histidine rich glycoproteinunclassified drugarticlechromosome 3gene assignmenthumanhuman cellAnimalBlotting, SouthernChromosome MappingChromosomes, Human, Pair 3GenesGlycoproteinsHumanHybrid CellsProteinsRodentia
TNO Identifier
231195
Repository link
https://resolver.tno.nl/uuid:f30814d9-a15e-4462-815d-eb71a4c7a883
ISSN
08887543
Source
Genomics, 7(2), pp. 276-279.
Pages
276-279
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