Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia
article
In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the Dutch population. Differences in pre-treatment lipid levels were not related to the apoE polymorphism in this FH population. After 12 weeks use of a daily dose of 40 mg simvastatin, the plasma total cholesterol, low density lipoprotein (LDL)-cholesterol and plasma triglyceride levels were reduced on average by 33%, 38% and 19%, respectively. At the same time high density lipoprotein (HDL)-cholesterol concentration increased on average by 7%. In the combined FH patient group (males and females) a considerable interindividual variation in response to simvastatin was observed, we found that female FH patients with the apoE3E3 phenotype responded better on simvastatin treatment with respect to LDL-cholesterol than male FH patients with the apoE3E3 phenotype.
Chemicals/CAS: Anticholesteremic Agents; Apolipoproteins E; Lovastatin, 75330-75-5; Simvastatin, 79902-63-9
Chemicals/CAS: Anticholesteremic Agents; Apolipoproteins E; Lovastatin, 75330-75-5; Simvastatin, 79902-63-9
Topics
apolipoprotein Echolesterolfamilial hypercholesterolemiagenetic polymorphismsimvastatinapolipoprotein echolesterollow density lipoproteinsimvastatintriacylglycerolarticlefamilial hypercholesterolemiahumanmajor clinical studyoral drug administrationpriority journalAdultAgedAnticholesteremic AgentsApolipoproteins EFemaleHeterozygoteHumanHypercholesterolemia, FamilialLovastatinMaleMiddle AgePhenotypePolymorphism (Genetics)Sex FactorsSimvastatinSupport, Non-U.S. Gov't
TNO Identifier
231191
ISSN
00219150
Source
Atherosclerosis, 83(1), pp. 89-97.
Pages
89-97
Files
To receive the publication files, please send an e-mail request to TNO Repository.