Pharmacokinetics of hexobarbital in young and old rats

article

Boonstra-Nieveld, I.H.J.

Bezooijen, C.F.A. van
Hexobarbital is a drug widely used to study the capacity of the liver to metabolize drugs. The pharmacokinetics of hexobarbital in 3- and 30-month-old male BN/BiRij rats were studied. The half-life of hexobarbital in 30-month-old rats (34.9 ± 4.1 min) was significantly higher than that of 3-month-old ones (21.3 ± 3.8 min). The volume of distribution (ml·kg-1 body weight) did not change with age. The intrinsic clearance, expressed as ml·min-1·kg-1 body weight, of hexobarbital in 30-month-old rats (20.2 ± 6.6) was half that of the 3-month-old ones (39.5 ± 7.6). Further studies will be performed to investigate the effect of age on the intrinsic clearance of S(+)- and R(-)- hexobarbital. Chemicals/CAS: Hexobarbital, 56-29-1
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AgeingHexobarbitalPharmacokineticsRathexobarbitaladolescentageagedanimal experimentblood leveldrug half lifeintravenous drug administrationAge FactorsAnimalBody WeightChromatography, High Pressure LiquidHexobarbitalLiverMaleOrgan WeightRatsRats, Inbred BNAnimalia
TNO Identifier
231016
Repository link
https://resolver.tno.nl/uuid:0ca3591e-9bd1-45f0-ab18-9e342062fd02
ISSN
00476374
Source
Mechanisms of Ageing and Development, 50(3), pp. 289-298.
Pages
289-298
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