Applicability of continuous-flow fast atom bombardment liquid chromatography-mass spectrometry in bioanalysis. Dextromethorphan in plasma

article



Kokkonen, P.

Niessen, W.M.A.

Tjaden, U.R.

Greef, J. van der
Continuous-flow fast atom bombardment (CF-FAB) is an interface for combined liquid chromatography-mass spectrometry using FAB as the ionization method. The applicability of CF-FAB for quantitative bioanalysis was studied for a model compound, dextromethorphan, in plasma samples using conventional high-performance liquid chromatography. The flow-rate reduction was achieved either by splitting or by the phase-system switching approach. The features of both systems are discussed.
Chemicals/CAS: dextromethorphan, 125-69-9, 125-71-3; Dextromethorphan, 125-71-3; Levorphanol, 77-07-6
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dextromethorphanfast atom bombardment ionizationliquid chromatographymass spectrometrymethodologyplasmapriority journalChromatography, LiquidDextromethorphanHumanLevorphanolSpectrum Analysis, Mass
TNO Identifier
230809
Repository link
https://resolver.tno.nl/uuid:ccddc810-8de3-4528-a9b6-6699ab613f43
ISSN
00219673
Source
Journal of Chromatography, 474(1), pp. 59-68.
Pages
59-68
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