Familial elevation of plasma histidine-rich glycoprotein in a family with thrombophilia

article



Engesser, L.

Kluft, C.

Briet, E.

Brommer, E.J.P.
A patient with spontaneous venous thrombotic events, myocardial infarction and a positive family history of thrombosis was investigated for underlying disorders of haemostasis. Abnormally high levels of histidine-rich glycoprotein were found. No other abnormality known or suspected of increasing the risk for thrombosis was present. Elevated levels of histidine-rich glycoprotein appeared to be present in four other members of the family over two generations suggesting a hereditary disorder. Further study on the relation of elevated histidine-rich glycoprotein levels and thrombosis is indicated.
Chemicals/CAS: histidine, 645-35-2, 7006-35-1, 71-00-1; Blood Proteins; histidine-rich proteins
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glycoproteinhistidinecase reportfamilyhumanthrombophiliathrombosisAdolescentAdultBlood CoagulationBlood ProteinsCase ReportFemaleFibrinolysisHumanMaleMiddle AgePedigreeSupport, Non-U.S. Gov'tThrombosis
TNO Identifier
230495
Repository link
https://resolver.tno.nl/uuid:3ec44e0e-7dc0-4789-a786-60f8789e4ed1
ISSN
00071048
Source
British Journal of Haematology, 67(3), pp. 355-358.
Pages
355-358
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