Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: Pooled analysis of prospective cohort studies
article
Zhang, X.
Albanes, D.
Beeson, W.L.
Brandt, P.A. van den
Buring, J.E.
Flood, A.
Freudenheim, J.L.
Giovannucci, E.L.
Goldbohm, R.A.
Jaceldo-Siegl, K.
Jacobs, E.J.
Krogh, V.
Larsson, S.C.
Marshall, J.R.
McCullough, M.L.
Miller, A.B.
Robien, K.
Rohan, T.E.
Schatzkin, A.
Sieri, S.
Spiegelman, D.
Virtamo, J.
Wolk, A.
Willett, W.C.
Zhang, S.M.
Smith-Warner, S.A.
BackgroundThe relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. MethodsWe investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. ResultsCompared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, Ptrend =. 68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, Ptrend =. 01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, Ptrend =. 91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P >. 20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P >. 05). ConclusionsDrinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. The Author 2010. Published by Oxford University Press. © The Author 2010.
TNO Identifier
360827
ISSN
00278874
Source
Journal of the National Cancer Institute, 102(11), pp. 771-783.
Pages
771-783
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