Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity

article








Knijnenburg, A.D.

Spalburg, E.

Neeling, A.J. de

Mars-Groenendijk, R.H.

Noort, D.

Grotenbreg, G.M.

Marel, G.A. van der

Overkleeft, H.S.

Overhand, M.
(Chemical Equation Presented) A series of ring-extended gramicidin S (GS) derivatives containing furanoid sugar amino acids were evaluated. Although the extended GS derivatives have a less well-defined secondary structure as determined by NMR and CD, some derivatives show an improved biological profile, namely, an increased antibacterial activity and decreased hemolytic activity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Topics




β turnsAntibioticsCyclic peptidesGramicidin SSugar amino acids
TNO Identifier
275971
Repository link
https://resolver.tno.nl/uuid:e05a6988-d71a-4cc4-aa10-fa40dbb0020e
ISSN
1860-7179
Source
ChemMedChem, 4(12), pp. 1976-1979.
Pages
1976-1979
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