Fibrinogen, plasminogen and tissue-type plasminogen activator ; their role in the fibrinolytic system
conference paper
Disbalance between clot formation (coagulation) and dissolution (fibrinolysis) can cause thrombotic or bleeding events, depending on which of the two processes predominates. During fibrinolysis, insoluble fibrin is degraded to soluble fragments by plasmin, which can be formed by activation of plasminogen by tissue-type plasminogen activator (t-PA). Fibrin is not merely a plasmin substrate but also accelerates the t-PA mediated plasminogen activation. This acceleration is probaby due to mutual interactions between plasminogen, t-PA and fibrin. Knowledge of the three-dimensional structure, as can be obtained by X-ray analysis of crystals of the three proteins, will contribute to the understanding of the mechanism of the physiologically important phenomenon of the accelerated plasmin formation in the presence of fibrin.
Topics
TNO Identifier
229625
ISSN
03796566
Publisher
ESA Scientific & Technical Publ Branch
Source title
Protein Single Crystal Growth under Low Gravity, Proceedings of a Joint ESA-DFVLR Workshop., Freiburg, West Ger, Conference code: Conference code: 5686
Editor(s)
Guyenne T.D.
Hunt J.J.
Hunt J.J.
Place of publication
Noordwijk
Pages
15-17
Files
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