Evidence for the occurrence of a fast-acting inhibitor for tissue-type plasminogen activator in human plasma
article
Human plasma contains a fast-acting t-PA inhibitor, which is not identical with ??2-antiplasmin or ??2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t-PA (0-2 IU/ml). The inhibitor binds to concanavalin A-Sepharose, is rather stable when heated, is not precipitated in euglobulin fractions and probably does not originate from platelets. The inhibitor seems to form a 190 Kd complex with t-PA. The relation between this plasma inhibitor and the recently discovered endothelial cell inhibitor is not yet clear. Chemicals/CAS: plasminogen activator, 9039-53-6; Glycoproteins; Iodine Radioisotopes; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators
Topics
TNO Identifier
229582
ISSN
03406245
Source
Thrombosis and Haemostasis, 51(3), pp. 392-395.
Pages
392-395
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