The reticuloendothelial system and aging: A review

article

Brouwer, A.

Knook, D.L.
This review represents an attempt to summarize and evaluate the literature data on the changes occurring in the reticuloendothelial system (RES) during aging. The RES is briefly introduced with emphasis on cellular composition, function, physiology, regulation and the methods employed for assessment of its functions. The age-related changes in the RES are discussed in terms of endocytotic capacity, antimicrobial and antitumor activity and morphology. In addition, the cooperation between the RES and the immune system in the defence of the body against disease agents is discussed in relation to the increased susceptibility to infectious diseases and tumorigenesis in both man and experimental animals during aging. Chemicals/CAS: Colloids
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agedcarcinogenesiscolloid clearanceetiologyhost resistanceinfectionmacrophagenormal humanreticuloendothelial systemreviewAgingAnimalCarcinoma, Ehrlich TumorColloidsEndocytosisGuinea PigsHumanImmunity, NaturalKineticsMacrophagesMiceNeoplasm MetastasisPhagocytosisRabbitsRatsReticuloendothelial System
TNO Identifier
229474
Repository link
https://resolver.tno.nl/uuid:8b138f39-079e-4842-a8cd-4101a9e402f4
ISSN
00476374
Source
Mechanisms of Ageing and Development, 21(3-4), pp. 205-228.
Pages
205-228
Files
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