Concomitant increase in hepatic triacylglycerol biosynthesis and cytosolic fatty-acid-binding-protein content after feeding rats with a cholestyramine-containing diet

article



Kempen, H.J.M.

Glatz, J.F.C.

Lange, J.de

Veerkamp, J.H.
Cholestyramine feeding of rats increased the rate of palmitate and glycerol incorporation into triacylglycerols of isolated hepatocytes. Concomitantly an increase of fatty-acid binding by hepatic cytosolic proteins was observed, which could be attributed to an elevation of the content of the fatty-acid-binding protein (M(r) 12,000). The involvement of this protein in cholesterol, bile-acid and triacylglycerol metabolism is discussed. Chemicals/CAS: cholesterol, 57-88-5; colestyramine, 11041-12-6, 58391-37-0; Carrier Proteins; Cholestyramine, 11041-12-6; fatty acid-binding proteins; Palmitic Acid, 57-10-3; Palmitic Acids; Triglycerides
Topics























bile acidcholesterolfatty acid binding proteinradioisotopeanimal celldietdrug metabolismlivernonhumanpalmitic acid c 14AnimalCarrier ProteinsCholestyramineChromatography, GelCytosolKineticsLiverMalePalmitic AcidPalmitic AcidsRatsRats, Inbred StrainsStimulation, ChemicalTriglycerides
TNO Identifier
229456
Repository link
https://resolver.tno.nl/uuid:e6f5847b-ed9a-440e-ae52-b04a7644529f
ISSN
0264-6021
Source
Biochemical Journal, 216(2), pp. 511-514.
Pages
511-514
Files
To receive the publication files, please send an e-mail request to TNO Repository.