Tissue damage and nutritional factors in experimental respiratory tract (co-)carcinogenesis

article




Reuzel, P.G.J.

Feron, V.J.

Spit, B.J.

Beems, R.B.

Kroes, R.
Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and nutrients such as vitamin A and saturated and unsaturated fats. In addition, the effects of a combined exposure to four different major gaseous cigarette smoke components - methyl nitrate, isoprene, methyl chloride and acetaldehyde - and to one solid cigarette smoke component - norharman - were examined in short- and long-term inhalation studies. An interesting finding was the charcinogenicity of acetaldehyde, of which the possible mechanism is briefly discussed. Another conspicuous observation was the substantial increase in number and size of lipid droplets in alveolar fibroblasts of hamsters fed a high vitamin A diet. Chemicals/CAS: acetaldehyde, 75-07-0; benzo[a]pyrene, 50-32-8; beta carboline, 244-63-3; isoprene, 78-79-5; methyl chloride, 74-87-3; retinol, 68-26-8, 82445-97-4; Acetaldehyde, 75-07-0; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Glass
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AcetaldehydeBenzo[a]pyreneBeta carbolineCigarette smokeIsopreneMethyl chlorideRetinolTobacco smokeBenzo[a]pyrene derivativeGlassAnimal experimentBiological modelCarcinogenesisChemical carcinogenesisDrug administrationDrug efficacyDrug interactionEpitheliumEtiologyFoodHamsterHistologyInhalational drug administrationLungMethodologyMethyl nitrateNonhumanOral drug administrationRespiratory systemRespiratory tract cancerScarTracheaAnimalArticleCocarcinogenesisExperimental neoplasmIatrogenic diseaseNutritionPathologyPlantRespiratory tract tumorSmokeTobaccoAnimaliaCricetinaeMesocricetus auratusNicotiana tabacumAcetaldehydeAnimalBenzo(a)pyreneBenzopyrenesCocarcinogenesisGlassNeoplasms, ExperimentalPlants, ToxicRespiratory Tract NeoplasmsSupport, Non-U.S. Gov't
TNO Identifier
229431
Repository link
https://resolver.tno.nl/uuid:8e9ffcc2-3be9-412c-951d-749b5d81419d
ISSN
00916765
Source
Environmental Health Perspectives, 50, pp. 275-283.
Pages
275-283
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