Meclofenoxate decreases protein and albumin synthesis in hepatocytes isolated from old rats
article
Protein-synthesizing activity was studied in hepatocytes isolated from rats of various ages with or without treatment with 80 mg meclofenoxate/day per kg body weight for 2 weeks. The substance did not influence protein synthesis in hepatocytes isolated from 3- and 12-month-old rats, but drastically decreased the synthesis of protein by hepatocytes isolated from 24-, 31- and 36-month-old rats. A comparable effect was observed for the liver-specific function of albumin synthesis. The absence of any stimulating effect of meclofenoxate treatment was also observed for another liver-specific function, viz. the BSP storage capacity. Therefore, the conclusion can be drawn that meclofenoxate at the doses and times of treatment studied does not stimulate the functional capacities of old hepatocytes. Chemicals/CAS: bromsulfophthalein, 71-67-0; meclofenoxate, 3685-84-5, 51-68-3; Albumins; Glycolates; Meclofenoxate, 3685-84-5; Proteins; Sulfobromophthalein, 297-83-6.
Topics
TNO Identifier
229417
ISSN
00062952
Source
Biochemical Pharmacology, 32(14), pp. 2281-2283.
Pages
2281-2283
Files
To receive the publication files, please send an e-mail request to TNO Repository.