Relative absorption and dermal loading of chemical substances: Consequences for risk assessment

article


Buist, H.E.

Schaafsma, G.

Sandt, J.J.M. van de
Quantification of skin absorption is an essential step in reducing the uncertainty of dermal risk assessment. Data from literature indicate that the relative dermal absorption of substances is dependent on dermal loading. Therefore, an internal exposure calculated with absorption data determined at a dermal loading not comparable to the actual loading may lead to a wrong assessment of the actual health risk. To investigate the relationship between dermal loading and relative absorption in a quantitative manner, 138 dermal publicly available absorption experiments with 98 substances were evaluated (87 in vitro, 51 in vivo; molecular weight between 40 and 950, log P between -5 and 13), with dermal loading ranging mostly between 0.001 and 10 mg/cm2. In 87 experiments (63%) an inverse relationship was observed between relative dermal absorption and dermal loading, with an average decrease of factor 33 ± 69. Known skin irritating and volatile substances less frequently showed an inverse relationship between dermal loading and relative absorption. © 2009 Elsevier Inc. All rights reserved.
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Food and Chemical Risk AnalysisDermal absorptionDermal loadingIn vitroIn vivoRisk assessmentSkin irritation1 methyl 2 pyrrolidinone2 ethoxyethanolAminolevulinic acidAminolevulinic acid hexyl esterAminolevulinic acid methyl esterAtrazineAzinphos methylBenzo[a]pyreneBenzoic acidCatecholChemical compoundDisulfotonFlurbiprofenHexachlorobenzeneHydrocortisoneIbuprofenIprodioneMalathionMevinphosNaloxoneParathionPentachlorophenolPesticidePhosmetPyreneTestosteroneTriclosanTrimethylamineVolatile agentZinc chlorideHealth hazardHumanIn vitro studyIn vivo studyMolecular weightNonhumanPriority journalRisk assessmentSkin absorptionSkin irritation
TNO Identifier
241662
Repository link
https://resolver.tno.nl/uuid:e9ae718f-3254-471d-8fab-03aa4052f1f6
ISSN
02732300
Source
Regulatory Toxicology and Pharmacology, 54(3), pp. 221-228.
Pages
221-228
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