Lactotripeptides and antihypertensive effects: A critical review
article
Hypertension or high blood pressure is a significant health problem worldwide. Typically, lifestyle changes, including adopting a healthy diet, are recommended for people with an elevated blood pressure. Lactotripeptides are bioactive milk peptides with potential antihypertensive properties in man. These peptides, as part of a food product or as nutraceutical, may contribute to the prevention and treatment of hypertension. This paper reviews the current evidence of the blood pressure control properties of lactotripeptides in man. Blood pressure-lowering effects of lactotripeptides are typically measured after 4-6 weeks of treatment. However, in some cases, a blood pressure response has been observed after 1-2 weeks. Maximum blood pressure reductions approximate 13 mmHg (systolic blood pressure) and 8 mmHg (diastolic blood pressure) after active treatment compared with placebo, and are likely reached after 8-12 weeks of treatment. Effective dosages of lactotripeptides range from 3.07 to 52.5 mg/d. Evidence indicates that lactotripeptides are only effective at elevated blood pressure; no further lowering of normal blood pressure has been observed. Concomitant intake of antihypertensive medication does not seem to influence the potency of lactotripeptides to lower blood pressure. Similarly, ethnicity has not been found to influence the extent of lactotripeptide-induced blood pressure lowering. Based on the currently available data, lactotripeptides appear to be safe and effective. Thus, they can be part of a healthy diet and lifestyle to prevent or reduce high blood pressure.
Topics
Biomedical ResearchAntihypertensive effectsBlood pressureLactotripeptidesMilk peptidesantihypertensive agentBeta adrenergic receptor blocking agentCalcium antagonistDipeptidyl carboxypeptidase inhibitorLactotripeptide derivativePlaceboUnclassified drugAbsence of side effectsAntihypertensive activityAntihypertensive therapyBlood chemistryBlood pressure regulationCaucasianClinical trialDiastolic blood pressureDose responseDose time effect relationDrug bioavailabilityDrug efficacyDrug megadoseDrug potencyDrug safetyFood intakeHumanHypertensionJapaneseLow drug doseNonhumanRace differenceReviewSide effectSystolic blood pressureTreatment duration
TNO Identifier
241632
ISSN
00071145
Source
British Journal of Nutrition, 101(6), pp. 776-786.
Pages
776-786