Adenocarcinomas of the prostate induced by n-nitroso-n-methylurea in rats pretreated with cyproterone acetate and testosterone
article
Prostatic adenocarcinomas were induced in 5 out of 20 Wistar rats upon a single administration of 50 mg/kg N-nitroso-N-methylurea (NMU). The rats were pretreated with a daily dose of 50 mg/kg cyproterone acetate for 3 weeks followed by 3 daily injections of 100 mg/kg testosterone. All tumours developed in the dorsolateral prostate and were invasively growing. In 2 cases distant metastases were found. Three proliferative lesions classified as carcinomas in situ were also found in the dorsolateral prostate. A total of 7/20 animals (35%) carried an adenocarcinoma and/or a carcinoma in situ. In addition, 6 epithelial hyperplasias were observed in the dorsolateral and 1 in the ventral prostate of non-tumour-bearing rats. The method described may provide a good animal model for cancer of the prostate and lead to a better understanding of prostatic carcinogenesis. Chemicals/CAS: cyproterone acetate, 427-51-0; methylnitrosourea, 684-93-5; testosterone propionate, 57-85-2; testosterone, 58-22-0; Cyproterone Acetate, 427-51-0; Cyproterone, 2098-66-0; Methylnitrosourea, 684-93-5; Nitrosourea Compounds; Testosterone, 57-85-2
Topics
Cyproterone acetateMethylnitrosoureaTestosteroneTestosterone propionateAnimal experimentChemical carcinogenesisMale genital systemNonhumanProstate cancerRatAdenocarcinomaAnimalCarcinoma in SituCocarcinogenesisCyproteroneCyproterone AcetateMaleMethylnitrosoureaModels, BiologicalNeoplasm MetastasisNeoplasms, ExperimentalNitrosourea CompoundsProstatic NeoplasmsRatsRats, Inbred StrainsSupport, Non-U.S. Gov'tTestosterone
TNO Identifier
229346
ISSN
03043835
Source
Cancer Letters, 18(1), pp. 69-78.
Pages
69-78
Files
To receive the publication files, please send an e-mail request to TNO Repository.