Acute inhalation toxicity study of ammonia in rats with variable exposure periods
article
The acute inhalation toxicity of ammonia was examined in rats using various exposure concentrations and exposure periods. Groups of male and female rats were exposed to dynamic atmospheres containing different concentrations of ammonia for 10, 20, 40 or 60 min. The aim of the study was to establish the relationship between exposure concentration and exposure period and mortality. The correlation between exposure concentration (c), exposure period (t) and mortality rate, expressed in probits was found to be Probit = 2.30 1n [c(2.02) x t] - 47.8. The following LC50 values for ammonia were calculated: 10min LC50 : 28,130 mg/m3 air (40,300 ppm); 20 min LC50 : 19,960 mg/m3 (28,595 ppm); 40 min LC50 : 14,170 mg/m3 air (20,300 ppm); 60 min LC50 : 11,590 mg/m3 air (16,600 ppm). Chemicals/CAS: ammonia, 14798-03-9, 51847-23-5, 7664-41-7; Ammonia, 7664-41-7
Topics
TNO Identifier
229288
ISSN
15298663
Source
American Industrial Hygiene Association Journal, 43(9), pp. 662-665.
Collation
4 p.
Pages
662-665
Files
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