The bradykinin B2 receptor in the early immune response against Listeria infection
article
The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B2 (B2R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B2R (B2R-/- mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with Listeria monocytogenes. Levels of cytokines known to play a pivotal role in the early phase immune response against L. monocytogenes, IL-12p70 and IFN-γ, were reduced in B2R-/- mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells. Thus, we show that bradykinin and the B2R play a role in early innate immune functions during bacterial infection. © 2008 Springer-Verlag.
Topics
BradykininCytokinesKnock out miceListeria monocytogenesBradykinin B2 receptorGamma interferonInterleukin 12p70Animal experimentAnimal modelArticleControlled studyCytokine productionDendritic cellImmune responseLsteria monocytogenesListeriosisMonocyteMouseNonhumanPriority journalProtein functionWeight reductionAnimalsBody WeightBradykininCells, CulturedCytokinesDendritic CellsHumansInterferon-gammaInterleukin-12Listeria InfectionsListeria monocytogenesLiverMiceMice, KnockoutReceptor, Bradykinin B2
TNO Identifier
241382
ISSN
0300-8584
Source
Medical Microbiology and Immunology, 198(1), pp. 39-46.
Pages
39-46
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