Tissue culture and neurotoxicology

article
Hooisma, J.
Application of tissue culture in neurotoxicology may serve two purposes. First, they may be used to unravel the mechanism of action of neurotoxic compounds and secondly, they may be used for the screening of neurotoxic agents. Studies belonging to the first group can be subdivided into those aiming at the replication of neurotoxic processes in vivo and into those concerned with non-specific effects of neurotoxicants on cultured cells. The potential usefulness of these types of studies for the development of screening methods is discussed. An investigation of acrylamide neurotoxicity in cultures of cerebral cells serves to illustrate such an approach. Chemicals/CAS: acrylamide, 79-06-1; colchicine, 64-86-8; glutathione, 70-18-8; nicotinamide adenine dinucleotide, 53-84-9; Acrylamide, 79-06-1; Acrylamides; Colchicine, 64-86-8; Glutathione, 70-18-8; NAD, 53-84-9
Topics




































AcrylamideColchicineGlutathioneNicotinamide adenine dinucleotideAnimal cellBrain cellCentral nervous systemDose responseDrug comparisonDrug mechanismDrug mixtureDrug responseDrug screeningIn vitro studyIntoxicationMethodologyNervous systemNeurotoxicityNonhumanRatTissue cultureAcrylamideAcrylamidesAnimalAxonsColchicineFemaleGanglia, SpinalGlutathioneMaleNADNervous System DiseasesRatsRats, Inbred StrainsSupport, Non-U.S. Gov'tTissue CultureToxicology
TNO Identifier
229278
Repository link
https://resolver.tno.nl/uuid:fbcef675-4acf-4dee-898f-758259940671
ISSN
02751380
Source
Neurobehavioral Toxicology and Teratology, 4(6), pp. 617-622.
Pages
617-622
Files
To receive the publication files, please send an e-mail request to TNO Repository.