Synthesis and biological evaluation of novel gramicidin s analogues
article
The synthesis of three new analogues of the cyclic cationic antimicrobial peptide Gramicidin S is described. These derivatives contain a modified turn region in which the DPhe-Pro motif has been replaced by a constrained furanoid sugar amino acid or a flexible linear aminoethoxy acetic acid moiety. Structural analysis revealed conformational changes in the modified turn region compared to GS. The biological profile of these compounds however resembles that of Gramicidin S and previously described analogues. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
TNO Identifier
183954
ISSN
1434-193X
Source
European Journal of Organic Chemistry(25), pp. 4231-4241.
Pages
4231-4241
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