Glucagon receptors: Are they present on human blood cells?

article


Hinsbergh, V.W.M. van

Nooijen, W.J.

Kempen, H.J.M.
Binding of glucagon to and its degradation by human mononuclear leukocytes and erythrocytes was investigated. Labeled glucagon binds to these cells, but can be displaced only by unlabeled glucagon at pharmacologically high concentrations. It is concluded that glucagon binding to human blood cells does not represent receptors of physiological importance and is of no value to the determination of glucagon sensitivity in man. Chemicals/CAS: Glucagon, 9007-92-5; Receptors, Cell Surface; Receptors, Glucagon
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drug receptorglucagon receptorinsulin i 125radioisotopeblood and hemopoietic systemendocrine systemerythrocyteglucagon i 125glucagon i 127human cellin vitro studyleukocytemonocytenormal humanAnimalBlood CellsErythrocytesGlucagonHumanLiverLymphocytesMonocytesRatsReceptors, Cell SurfaceReceptors, Glucagon
TNO Identifier
229232
Repository link
https://resolver.tno.nl/uuid:5c4ee9c3-85bd-40bd-a32e-9648d6bfb611
ISSN
00185043
Source
Hormone and Metabolic Research, 14(2), pp. 65-68.
Pages
65-68
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