Reduction of polyneuronal innervation of muscle cells in tissue culture after long-term indirect stimulation
article
In combined cultures of chick muscle cells and ciliary ganglia, the effect of indirect, long-term stimulation on the number of neuromuscular contacts on individual muscle cells was studied. Seven days of phasic stimulation resulted in a marked reduction in the number of neuromuscular contacts, the majority of the muscle cells becoming innervated by only one neuron. Neuromuscular blockade by D-tubocurarine prevented this loss of innervation. Chemicals/CAS: tubocurarine chloride, 57-94-3, 57-95-4, 8006-51-7
Topics
TNO Identifier
229177
ISSN
01653806
Source
Developmental Brain Research, 3(1), pp. 130-133.
Pages
130-133
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