Expression of the murine mammary tumor virus in the milk of F1 hybrids of virus negative mouse strains
article
Milk samples of multiparous females from several mouse strains and their F1 hybrids were tested for the presence of the envelope glycoprotein gp52 of the murine mammary tumour virus. F1 hybrids resulting from matings of the virus negative strain BALA/c with the virus negative strains AKR, ND2 or RFM were positive for the viral antigen. The progeny of backcrosses to either parent had considerably lower incidences of viral antigen-positive milks. It was concluded that different recessive genes in the BALB/c strain on the one hand and in the AKR, ND2 and RFM strain on the other cause inhibition of endogenous virus expression. In F1 hybrids the two sets of genes complement each other, resulting in virus release. Chemicals/CAS: Viral Envelope Proteins; Viral Proteins
Topics
GlycoproteinAnimal experimentBreastGenetic complementationHeredityHybrid f1Mouse mammary tumor oncovirusOncovirinaeVirus expressionAnimalFemaleGene Expression RegulationHybridization, GeneticMammary Tumor Virus, MouseMiceMice, Inbred StrainsMilkPregnancyRadioimmunoassayViral Envelope ProteinsViral Proteins
TNO Identifier
228965
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 17(8), pp. 883-888.
Pages
883-888
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