Sensitivity of several cell systems to acrylamide

article



Hooisma, J.

Groot, D.M.G.de

Magchielse, T.

Muijser, H.
Chick spinal ganglia, chick muscle cells combined with mouse spinal cord explants, C1300 neuroblastoma cells, Chinese hamster ovary cells and newborn rat cerebral cells were exposed to various concentrations of acrylamide in culture. Four morphological and 1 electrophysiological parameter were applied in order to score toxic effects. It appeared that the neurite formation of rat cerebral neurons was the most sensitive criterion showing an effect at 10-7 M acrylamide.
Chemicals/CAS: acrylamide, 79-06-1; Acrylamides
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Historisch materiaal TNO Central nervous systemCytotoxicityDose responseDrug responseEndocrine systemFemale genital systemHistologyIn vitro studyIntoxicationMuscle cellNervous systemNeuroblastoma cellNeurotoxicityOvary cellRatSpinal cordSpinal ganglionAcrylamidesAnimalBrainChickensGanglia, SpinalMiceMusclesNeuronsRabbitsTissue Culture
TNO Identifier
228933
Repository link
https://resolver.tno.nl/uuid:bfa2d9ad-c451-43d8-bdc2-cf2d58251faa
ISSN
0300483X
Source
Toxicology, 17(2), pp. 161-167.
Pages
161-167
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