Selective macrophage inhibition abolishes warfarin-induced reduction of metastasis

article
Maat, B.
Warfarin administered to tumor-bearing mice reduces the number of spontaneous lung metastases. Both macrophage inhibitors silica and carrageenan abolish the warfarin-induced decrease in tumour metastasis, which strongly supports the concept that the antitumour effect of coumarin derivatives is mediated by stimulation of macrophages. The results do not seem to be influenced by any effects of carrageenan on blood-coagulation factors. Chemicals/CAS: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; warfarin, 129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2; Carrageenan, 9000-07-1; Silicon Dioxide, 7631-86-9; Warfarin, 81-81-2
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blood clotting factorcarrageenansilicon dioxidewarfarinblood and hemopoietic systemblood clottingmacrophagemetastasisreticuloendothelial systemAnimalCarrageenanLung NeoplasmsMacrophagesMaleMiceNeoplasms, ExperimentalSilicon DioxideWarfarin
TNO Identifier
228851
Repository link
https://resolver.tno.nl/uuid:39935929-7b9f-4f83-85b9-94ae98ee3e5f
ISSN
00070920
Source
British Journal of Cancer, 41(2), pp. 313-316.
Pages
313-316
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