Expression of mammary tumour virus in late-appearing mammary carcinomas in presumed virus-free mice
article
Mammary tumours arising in mice which had been tested for the presence of mammary tumour virus (MuMTV) in the milk were tested for either the presence of infectious MuMTV by bioassay in female BALB/c mice or for the presence of the major MuMTV envelope glycoprotein gp52. In crosses involving the high cancer strain GRS, 16/17 tumours appearing before 1 yr of age contained a virulent virus. Only 2/19 of the late appearing tumours in virus positive mice, harboured a virus which induced tumours at an early age but 12 contained an infectious late-oncogenic MuMTV. In crosses involving the C3Hf mouse strain which develops tumours at a late age, only 2/28 tumours in virus positive mice contained a virulent MuMTV but 15 harboured a late-oncogenic strain. Of the 22 tumours which arose in so-called virus-negative mice in all crosses, 7 harboured an infectious MuMTV; it was highly virulent in 3 cases. In the immunoassay, all 41 tumours which developed in mice with virus positive milks were also positive for gp52. The majority (25/39) of tumours arising in virus negative mice were positive for the viral antigen, although the quantities were relatively low.
Chemicals/CAS: Antigens, Viral; Glycoproteins; Viral Proteins
Chemicals/CAS: Antigens, Viral; Glycoproteins; Viral Proteins
Topics
animal experimentbreastbreast carcinomamousemouse mammary tumor oncovirusoncovirinaevirus expressionAgingAnimalAntigens, ViralBiological AssayCrosses, GeneticFemaleGlycoproteinsMammary Neoplasms, ExperimentalMammary Tumor Virus, MouseMiceMice, Inbred StrainsSupport, U.S. Gov't, P.H.S.Viral ProteinsVirulence
TNO Identifier
228813
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 16(2), pp. 267-271.
Pages
267-271
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