Repeated exposure to butenolide vapour: Subacute study in Syrian golden hamsters
article
The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge, growth retardation, decreased number of eosinophils, increased liver weight, and hyper- and metaplastic epithelium in the nasal cavity. At the 5.4 and 25 ppm levels no changes were observed which could be attributed to butenolide; 25 ppm was, therefore, considered the highest no-toxic effect level observed. The actual no-adverse effect level was placed at 75 ppm. Chemicals/CAS: butenolide, 497-23-4; butenolide, 497-23-4; Furans
Topics
ButenolideAnimal experimentAutonomic nervous systemBlood and hemopoietic systemCentral nervous systemCigarette smokingDose responseDrug responseDrug toxicityEye irritationGrowth retardationInhalational drug administrationIntoxicationMouthRespiratory systemToxicityVisual systemAnimalBehavior, AnimalBody WeightEnvironmental ExposureFemaleFuransHamstersMaleMesocricetusNasal MucosaSmokingTime Factors
TNO Identifier
228736
ISSN
0300483X
Source
Toxicology, 15(1), pp. 65-68.
Pages
65-68
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