The expression of histocompatibility-2 antigens on hemopoietic stem cells
article
Antisera directed against histocompatibility-2 antigens of the mouse suppress the formation of spleen colonies by pluripotent hemopoietic stem cells. Of antisera which are specific for subregions of the H-2 complex, only those which contain anti-H-2K or anti-H-2D activity are effective. Specific anti-Ia sera do not react with the stem cell. If the titer of the CFU-s suppressive effect of the antisera is compared to their toxicity to spleen lymphocytes, it can be concluded that CFU-s express antigens in the same density as spleen lymphocytes. The amount of H-2 antigens expressed on the surface of CFU-s is independent of its rate of proliferation. Chemicals/CAS: Epitopes; H-2 Antigens; Immune Sera; Papain, EC 3.4.22.2
Topics
TNO Identifier
228639
ISSN
0001-2815
Source
Tissue Antigens, 13(1), pp. 45-52.
Pages
45-52
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