Multi-locus control of MLC reactions in rhesus monkeys
article
The genetic basis for MLC reactivity in rhesus monkeys was further investigated. Cells from an intra-RhLA recombinant monkey were MLC reactive with those of an SD-identical sib and with each of two sets of homozygous typing cells carrying either paternal haplotype. Also, cells from a pair of RhLA- identical sibs reacted in MLC with each other, as well as with three genotypically different siblings. This excludes control of MLC reactivity by the conventional D locus only. Thus the results selected for presentation provide formal evidence for the existence of at least one additional MLC locus, named D′. The possibility that D′ exerts its influence on MLC reactivity only after alloimmunization is discussed.
Topics
TNO Identifier
228445
ISSN
00937711
Source
Immunogenetics, 7(2), pp. 155-164.
Pages
155-164
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