Cellular immunity to the mammary tumour virus in mice bearing primary mammary tumours
article
The development of cellular immunity directed against the murine mammary tumor virus (MTV) during the growth of primary mammary tumors was studied in BALB/c, BALB/cfC3H and GR mice, by measuring leukocyte stimulation and leukocyte adherence inhibition in the presence of purified MTV. Leukocytes react against group-specific antigens of different MTV strains in these assays. Purified Rauscher murine leukemia virus was used as a control. In both assays, MTV-specific reactivity peaked at a tumor weight of about 1 g; afterwards, it almost completely disappeared. It increased again to about half of the original level when the tumor reached a weight of about 3 g. Peak blastogenesis of lymph node cells was observed at a tumor weight somewhat higher than when peak blastogenesis of spleen cells occurred. The possible causes of the general decrease and oscillation in the cellular immune response during tumor growth are discussed.
Chemicals/CAS: Antigens, Viral; Epitopes
Chemicals/CAS: Antigens, Viral; Epitopes
Topics
virus antibodybreast carcinomacellular immunityleukocyte adherencelymphocyte transformationmouse mammary tumor oncovirusAnimalAntigens, ViralEpitopesImmunity, CellularLeukocyte Adherence Inhibition TestLeukocytesLymphocyte ActivationMammary Neoplasms, ExperimentalMammary Tumor Virus, MouseMiceMice, Inbred BALB CMice, Inbred StrainsSupport, U.S. Gov't, P.H.S.
TNO Identifier
228256
ISSN
02775379
Source
European Journal of Cancer and Clinical Oncology, 13(6), pp. 503-510.
Pages
503-510
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