Inactivation of Escherichia coli by superoxide radicals and their dismutation products

article

Hemmen, J.J. van

Meuling, W.J.A.
E. coli cells are inactivated by the products of the reaction between dialuric acid and oxygen, of which the primary product is superoxide. The rate of inactivation is decreased by superoxide dismutase, by catalase, and by EDTA, whereas it is increased by addition of cupric ions or hydrogen peroxide. It is concluded that a toxic product is formed in a reaction involving superoxide, hydrogen peroxide, and metal ions, which might be the Haber-Weiss reaction, O2- + H2O2 → OH + OH- + O2. In radiation chemical experiments it is shown that this reaction does not occur in the absence of metal ions. Chemicals/CAS: catalase, 9001-05-2; dialuric acid, 444-15-5; edetic acid, 150-43-6, 60-00-4; hydrogen peroxide, 7722-84-1; oxygen, 7782-44-7; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; superoxide, 11062-77-4; Catalase, EC 1.11.1.6; Edetic Acid, 60-00-4; Free Radicals; Hydrogen Peroxide, 7722-84-1; Oxygen, 7782-44-7; Superoxide Dismutase, EC 1.15.1.1; Superoxides, 11062-77-4
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CatalaseDialuric acidEdetic acidHydrogen peroxideOxygenSuperoxideSuperoxide dismutaseEscherichia coliIn vitro studyMicroorganismTheoretical studyCatalaseEdetic AcidEscherichia coliFree RadicalsHydrogen PeroxideKineticsMathematicsOxygenSuperoxide DismutaseSuperoxides
TNO Identifier
228247
Repository link
https://resolver.tno.nl/uuid:894450d9-2698-4988-a790-60c7b38f1309
ISSN
00039861
Source
Archives of Biochemistry and Biophysics, 182(2), pp. 743-748.
Pages
743-748
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