Protein metabolism in the rat cerebral cortex in vivo and in vitro as affected by the acquisition enhancing drug piracetam
article
The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in slices.
Chemicals/CAS: piracetam, 7491-74-9; protein, 67254-75-5; Leucine, 61-90-5; Nerve Tissue Proteins; Piracetam, 7491-74-9; Pyrrolidinones
Chemicals/CAS: piracetam, 7491-74-9; protein, 67254-75-5; Leucine, 61-90-5; Nerve Tissue Proteins; Piracetam, 7491-74-9; Pyrrolidinones
Topics
PiracetamProteinRadioisotopeBrainBrain cortexIn vitro studyIntracerebroventricular drug administrationIntraperitoneal drug administrationIntravenous drug administrationLeucine h 3PharmacokineticsRatTheoretical studyAnimalCerebral CortexIn VitroLeucineMaleNerve Tissue ProteinsPiracetamPyrrolidinonesRatsStimulation, ChemicalTime Factors
TNO Identifier
228017
ISSN
00062952
Source
Biochemical Pharmacology, 25(20), pp. 2237-2240.
Pages
2237-2240
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