Attempts to transform murine hemopoietic cells by Rauscher leukemia virus

article


Bentvelzen, P.

Aarssen, A.M.

Brinkhof, J.
Primary Rauscher leukemia virus (RLV) induced myeloid leukemias can produce many small clones in agar in the absence of a factor needed for the proliferation of normal myeloid cells. It seems that leukemic cells can more efficiently utilize the small amount of colony stimulating factor (CSF) that it produced by them. At optimal stimulation by exogenous CSF, leukemic cells exhibit a poorer rate of proliferation than normal bone marrow cells. Hemopoietic cells can replicate the virus after infection in vitro. In some experiments, infection of normal bone marrow cells leads to the production of some cells with the same growth pattern as cells from primary leukemias.
Chemicals/CAS: colony stimulating factor, 62683-29-8
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colony stimulating factorbone marrow cellcell culturecell proliferationcell transformationchloromaetiologyhistologyin vitro studyleukovirusmicroorganismmousemurine leukemia virusmyeloid leukemiaoncovirinaerauscher leukemia virustheoretical studyvirus replicationAnimalBone Marrow CellsCell DivisionCell Transformation, NeoplasticClone CellsHematopoietic Stem CellsLeukemia, ExperimentalLeukemia, MyeloidMiceMice, Inbred BALB CRauscher VirusVirus Replication
TNO Identifier
227944
Repository link
https://resolver.tno.nl/uuid:a635fb12-9e66-4765-be2c-0df77fe9114e
Source
Bibliotheca Haematologica, 40, pp. 179-183.
Pages
179-183
Files
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